essica D’Lima writes that medicine is moving towards minimally invasive procedures, which have important patient-oriented benefits such as shorter hospitalization durations and lower risks for infections and complications. In this regard, microrobots have emerged as a promising medical tool due to their potential to reach tissues and body cavities that are hard to navigate into, and with far-reaching applications such as imaging, targeted therapy, and tissue engineering. However, the miniaturization of biomedical tools comes with certain challenges: precise actuation, motion control, and safety.
Swimming microorganisms are useful biomedical tools due to their self‐powered movement and controllable steering properties, based on biological propulsion and sensing. Thus far, mainly (magnetotactic) bacteria have been investigated, but they can be harmful for humans and biocompatibility tests are still lacking. Furthermore, bacteria require special culture conditions to maintain their stability, which might limit their biomedical applications.
A possible alternative to bacteria as microrobotic devices are microalgae, such as Chlamydomonas reinhardtii, which are easy to culture. However, these fast swimming cells are not magnetic and thus not steerable in the human body. In previous studies, microalgae have been magnetized by attaching magnetic nanocrystals onto them. The disadvantage of this approach is that the nanocrystals hamper the movement of the cells, preventing drugs from being easily attached onto them.
To this effect, a team of scientists has shown that microalgae can gain magnetotactic behavior by simply incorporating a magnetic element, the rare earth element terbium. Once the algae incorporate terbium ions, they demonstrate superparamagnetic behavior with magnetic moments comparable to those of magnetotactic bacteria. These magnetized microalgae can align themselves along an applied magnetic field, which guides them to swim in a directional motion. Biocompatibility tests with human and mouse cells show that these magnetized microalgae are not harmful and could be used as biohybrid microrobots. Furthermore, since the incorporated terbium is luminescent, the magnetotactic microalgae are easy to track in the human body.