Bloomfield Hills, MI-based Health Enhancement Products, Inc. (HEPI), in conjunction with Wayne State University’s Department of Nutrition and Food Science in the College of Liberal Arts and Sciences, has published, “ProAlgaZyme sub-fraction improves the lipoprotein profile of hypercholesterolemic hamsters, while inhibiting production of betaine, carnitine, and choline metabolites” in the Journal of Nutrition & Metabolism, describing tests showing the beneficial effects of the Company’s proprietary algal culture in supporting healthy cholesterol balance.

The fractions and isolates derived from the Company’s proprietary algae culture “PAZ” (formerly referred to as “ProAlgaZyme”) were shown to be a viable candidate for supporting healthy cholesterol balance, in sharp contrast to the control group. The project, led by Smiti Gupta, Ph.D., associate professor of nutrition and food science at Wayne State University, involved monitoring lipid metabolism in a widely accepted animal model for investigating human lipid metabolism. The scientific paper describes a follow-up study to the original research conducted by Gupta.

In the previous study, published in 2012, the test group consumed algal-infused water while simultaneously consuming a high fat diet. The algal fractions and isolates were shown to have a preventative beneficial effect against the negative effects of the high-fat diet on the animal’s plasma cholesterol levels. Specifically, the extracts significantly increased high-density lipoprotein cholesterol (HDL-C, aka “good” cholesterol), and reduced non-HDL cholesterol (“bad” cholesterol) and the ratio of total cholesterol/HDL-C, despite the ongoing consumption of high fat food.

The test subjects in the recent study consumed a high fat diet for four weeks, at which point they became hypercholesterolemic (i.e. they had high plasma cholesterol levels.). Subsequently, the animals were given the extracts for 0 (untreated), 3, 7, 10, 14, and 21 days while still on the high fat diet. The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet.

Specifically, “bad” cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts, compared to those who were not treated. Furthermore, increased levels of “good” cholesterol could be seen as early as Day Three for that same group. By Day 21, “good” cholesterol levels increased by 28% and “bad” cholesterol levels decreased by 30%.

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